Green tea appears to inhibit the spread of prostate cancer in a number of ways, says a study in the Dec. 1 issue of Cancer Research.
In research with mice, scientists from the University of Wisconsin and Case Western Reserve University in Cleveland found green tea polyphenols (GTP) target molecular pathways that control the proliferation and spread of prostate tumor cells. The polyphenols also inhibit the growth of blood vessels that feed prostate tumors.
"Consumption of GTP led to reduced levels of IGF-1 (insulin-like growth factor-1)," study senior author Hasan Mukhtar, of the department of dermatology at the University of Wisconsin, said in a prepared statement.
"GTP also led to increased levels of one of the binding proteins for IGF-1, the insulin growth factor binding protein-3. These observations bear significance in light of studies that indicate increased levels of IGF-1 are associated with increased risk of several cancers, such as prostate, breast, lung and colon," Mukhtar said.
Showing posts with label prostate cancer. Show all posts
Showing posts with label prostate cancer. Show all posts
Tuesday, November 17, 2009
Sunday, November 15, 2009
Faulty Gene Doubles Risk of Prostate Cancer
Men who are missing sections of the CHEK2 kinase gene -- which programs production of a chemical that alerts the body to DNA damage -- are nearly twice as likely to develop prostate cancer as other men, a new study finds.
Researchers assessed 2,000 Polish men who were diagnosed with prostate cancer between 1999 and 2005, and compared them to 5,500 healthy people.
The missing sections (exons 9 and 10) were noted in 15 (0.8 percent) of the prostate cancer patients and in 24 (0.4 percent) of the healthy people. In addition, the researchers noted the missing sections of the gene in four of the 249 men with a family history of prostate cancer.
The study authors calculated that the deletion of these sections of the gene nearly doubles risk of prostate cancer in general, and quadruples the risk in men with a family history of the disease.
This deletion may be fairly common among men from eastern Europe and the Balkans, the study authors added.
The research was published ahead of print in the Journal of Medical Genetics.
Researchers assessed 2,000 Polish men who were diagnosed with prostate cancer between 1999 and 2005, and compared them to 5,500 healthy people.
The missing sections (exons 9 and 10) were noted in 15 (0.8 percent) of the prostate cancer patients and in 24 (0.4 percent) of the healthy people. In addition, the researchers noted the missing sections of the gene in four of the 249 men with a family history of prostate cancer.
The study authors calculated that the deletion of these sections of the gene nearly doubles risk of prostate cancer in general, and quadruples the risk in men with a family history of the disease.
This deletion may be fairly common among men from eastern Europe and the Balkans, the study authors added.
The research was published ahead of print in the Journal of Medical Genetics.
